具有抗A549活性的新型4-甲氧糖化物来自Scutellaria barbata和Cordyceps kyushuensis的双向固体发酵
Huixin Cheng1, Ran Wen1, Jiajia Hu1
1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Chemistry & biodiversity
|June 5, 2025
概括
研究人员探索了来自Scutellaria barbata D. Don和Cordyceps kyushuensis的发酵产品,发现了新的化合物. 一些孤立的化合物在体外显示出对A549肺癌细胞的抑制作用.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- Scutellaria barbata D. Don是一种传统的药用草本.
- 科迪塞普斯 (Cordyceps kyushuensis) 是一种用于发酵的真菌.
- 双向固体发酵是一种先进的提取技术.
研究的目的:
- 从发酵的Scutellaria barbata D. Don. 中分离和描述新型化合物.
- 评估隔离化合物在A549细胞上的体外细胞毒性作用.
主要方法:
- 使用Cordyceps kyushuensis.使用Scutellaria barbata D. Don的双向固体发酵.
- 通过乙醇提取分离和结构阐明化合物.
- 在体外细胞毒性测定使用A549细胞系.
主要成果:
- 确定了五种新型的4-甲氧糖糖化物和一种新的循环.
- 还分离了36种已知的化合物.
- 化合物4,5,16,19,20,25,27,31,和37显示出对A549细胞的抑制活性.
- 化合物31的IC50为38.5微米.
结论:
- 化Scutellaria barbata D. Don与Cordyceps kyushuensis的发酵产生了各种生物活性化合物.
- 发现了具有修饰的甲氧基组的新型葡萄糖类.
- 几种分离的化合物具有针对肺癌细胞的潜在抗癌特性.
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