波维斯托尔E和F,从Psathyrella microrhiza CF-117891中分离的新 bis-Sesquiterpenes
Frederick Boye Annang1, Guiomar Pérez-Moreno2, Cristina Bosch-Navarrete2
1Fundación MEDINA, Granada, Spain.
Chemistry & biodiversity
|June 5, 2025
概括
研究人员从真菌Psathyrella microrhiza中分离出了新的化合物,即Bovistols E和F. 酸对抗Plasmodium falciparum活性中等,而新的牛对抗疟疾和查加斯病寄生虫缺乏活性.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 菌类学 菌类学是指菌类学.
背景情况:
- Psathyrella microrhiza是一种生物活性天然产品的来源.
- 甲及其衍生物已知具有多种生物活性.
研究的目的:
- 从Psathyrella microrhiza中分离和描述新的化合物.
- 评估隔离化合物的抗寄生虫活性,以对抗Plasmodium falciparum和Trypanosoma cruzi.
主要方法:
- 用生物活性引导的真菌提取物的分化.
- 使用质谱法 (MS) 和核磁共振 (NMR) 光谱法阐明结构.
- 在体外抗寄生虫测定.
主要成果:
- 分离了两种新的双六二烯,牛醇E和F.
- 酸的分离,这是一个已知的抗血性化合物.
- 酸显示了适度的抗Plasmodium falciparum 3D7活性 (EC50 = 17.8μM).
- 波维斯托尔E和F对P.falciparum或Trypanosoma cruzi.没有显著的活性.
结论:
- 帕萨希雷拉微型菌产生新型 bis-sesquiterpenes,没有观察到的抗寄生虫活性.
- 从这种真菌中分离出来的酸具有适度的抗质性质.
- 对相关化合物的进一步调查可能会产生更强大的抗寄生虫剂.
相关概念视频
Biosynthesis in Bacteria
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
Biosynthesis of Polysaccharides
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
Biosynthesis of Lipids
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...
Fungal Phylum Basidiomycota
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...


