炎症性肠病与乙性食道炎的关联:系统性审查和元分析
Russell Yanofsky1, Rohit Jogendran2, Tedi Hoxha2
1Division of Gastroenterology and Hepatology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Inflammatory bowel diseases
|June 5, 2025
概括
炎症性肠病 (IBD) 和亚托邦性皮肤炎与酸性食道炎 (EoE) 的更高可能性有关. 需要进一步的研究来了解这种关联背后的机制.
科学领域:
- 胃肠道学和免疫学
- 过敏和免疫学 过敏和免疫学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 和性食道炎 (EoE) 之间的关系尚未得到充分证实.
- 免疫介导的炎症性疾病与EoE有潜在的共同途径.
- 了解这些关联可以为诊断和治疗策略提供信息.
研究的目的:
- 系统地审查和元分析EoE和IBD之间的关联.
- 调查EoE和其他免疫媒介炎症疾病之间的联系.
- 为了比较IBD患者的EoE患病率与对照人群.
主要方法:
- 在主要数据库 (MEDLINE,Embase,Cochrane) 进行系统的文献搜索,直到2023年7月.
- 对38项符合条件的研究进行了元分析,比较了EoE诊断频率.
- 使用95%置信区间 (CI) 计算赔率比率 (ORs) 并评估异质性 (I2值).
主要成果:
- 与一般人群相比,IBD (OR 3.9) 患者的EoE诊断几率明显更高.
- 在性结肠炎和克罗恩病患者之间没有发现EoE患病率的显著差异.
- 在阿托皮性皮肤炎患者中,EoE也显著增加 (OR 2.4).
结论:
- 无论是IBD还是阿托皮性皮肤炎,都与EoE诊断的可能性增加有关.
- 这些发现表明潜在的共享病理生理学或风险因素.
- 对潜在机制进行进一步调查是有必要的.
相关概念视频
Chronic Bowel Disorders: Introduction
544
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
544
Inflammatory Bowel Disease II: Crohn's Disease
402
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
402
Inflammatory Bowel Disease I: Ulcerative Colitis
348
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
348
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
432
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
432
Barrett Esophagus-II: Clinical Manifestations and Management
321
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
321
Gastroesophageal Reflux Disease II: Clinical Features and Management
222
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
222


