婴儿肠道微生物组与幼儿的消极影响之间的纵向关联
Sarah C Vogel1, Nicolas Murgueitio2, Nicole Huth1
1Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Development and psychopathology
|June 5, 2025
概括
2周的婴儿肠道微生物群多样性与以后的负面影响有关. 婴儿时期的特定细菌也与儿童行为相关,这突显了测量时间的重要性.
科学领域:
- 发展心理学是发展心理学.
- 微生物组研究的研究.
- 儿科卫生保健 儿科卫生保健
背景情况:
- 越来越多地研究了肠道微生物组在婴儿发育和肠-大脑连接中的作用.
- 以前的研究表明,婴儿肠道微生物组合和气质之间存在联系,就像负面影响一样.
- 研究中不一致的发现突显了需要采用多种评估方法进行纵向研究的需要.
研究的目的:
- 研究婴儿肠道微生物组与负面影响之间的纵向关联.
- 检查不同婴儿年龄的肠道微生物群多样性和特定细菌属如何与后来的儿童行为有关.
- 了解肠道微生物组评估时间对与负面影响观察到的关联的影响.
主要方法:
- 一项涉及婴儿和照顾者的纵向研究.
- 在两个婴儿时间点评估肠道微生物组组成:2周和18个月.
- 在30个月大时测量的负面影响.
主要成果:
- 2周大时肠道微生物群多样性更高与30个月后观察到的负面影响增加有关.
- 婴儿肠道微生物组中的特定细菌属显示与负面影响的关联.
- 肠道微生物组测量的时间影响了观察到的与儿童行为的关联.
结论:
- 婴儿肠道微生物组的多样性和组成与以后的负面影响有关.
- 肠道微生物组与儿童行为之间的关系可能取决于微生物组被评估的发育阶段.
- 这些发现强调了早期肠道微生物和神经发育轨迹之间的动态相互作用.
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