老年人脆弱性和非高密度胆固醇之间的U形关系:一个横截面研究
Yu Pan1, Yan Yuan1, Juan Yang2
1Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
非高密度脂蛋白胆固醇 (非高密度脂蛋白胆固醇) (非HDL-C) 显示了与老年人虚弱的U形联系. 最佳的非HDL-C水平可能会降低脆弱性风险,而非常低或很高的水平会增加风险.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 代谢研究研究 代谢研究
背景情况:
- 脂质新陈代谢调节是治疗脆弱性的潜在治疗点.
- 非高密度脂蛋白胆固醇 (非HDL-C) 和脆弱性之间的特定关系尚未得到充分证实.
研究的目的:
- 为了研究非HDL-C和老年人的虚弱之间的联系.
- 探索潜在的非线性关系,并确定最佳的非HDL-C范围的脆弱性风险.
主要方法:
- 利用了来自NHANES和CHARLS研究的数据.
- 开发了一种40项脆弱指数尺度.
- 使用LASSO回归,物流回归和光梯度增强机 (LightGBM) 进行变量选择和模型开发.
主要成果:
- 确定了非HDL-C和脆弱性之间的U形非线性关联.
- 在117.54194.64 mg/dL的非HDL-C范围内观察到较低的脆弱风险.
- 脆弱性风险增加与非HDL-C水平的47.9963.87 mg/dL或274.01259.65 mg/dL有关.
结论:
- 建议在老年人中非HDL-C和脆弱性之间存在复杂的非线性关联.
- 需要进一步的严格研究来证实这些发现及其临床影响.
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