蔓越提取物对大鼠因印梅他辛诱导的胃的潜在影响
Zaid Abdul-Majeed1, Mohammed Qasim Yahya Malallah A Al-Atrakji1
1Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Baghdad Governorate, +964, Iraq.
蔓越提取物在大鼠中显著减少因印米他辛引起的胃. 这种天然疗法表现出抗炎和抗氧化作用,为抗NSAID诱导的毒性提供了有前途的胃保护策略.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 自然产品化学 自然产品化学
背景情况:
- 非类固醇抗炎药物 (NSAIDs),如印米他辛,广泛用于类风湿性疾病,但可能导致胃.
- 蔓越富含多和黄,以其强大的抗氧化和抗炎作用而闻名.
研究的目的:
- 在大鼠模型中研究蔓越水性提取物对因多美素诱导的胃的胃保护作用.
- 评估蔓越提取物对胃损伤中的炎症和氧化应激生物标志物的影响.
主要方法:
- 成年雄性白色老鼠被分为四组:对照组,因印梅他素引起的,梅治疗和蔓越提取物治疗.
- 经过15天的治疗,胃组织经过生物化学和组织病理学分析.
- 测量了瘤亡因子-α (TNF-α),际白素-6 (IL-6),超氧化脱氧化酶 (SOD) 和谷氨过氧化酶 (GPx) 的血清水平.
主要成果:
- 蔓越提取物显著改善了因印梅他素引起的胃的严重程度,改善了组织学损伤.
- 用蔓越提取物治疗的老鼠显示炎症生物标志物 (TNF-α,IL-6) 的水平降低,抗氧化生物标志物 (SOD,GPx) 的水平增加.
- 胃保护作用归因于蔓越提取物中的生物活性黄和多.
结论:
- 蔓越水性提取物在老鼠中表现出显著的胃保护性活性,对抗因印梅他辛诱导的胃.
- 蔓越的抗氧化和抗炎性质是其治疗潜力的关键.
- 蔓越提取物代表了一种有希望的自然策略,以减轻NSAID诱导的胃毒性.
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