相关实验视频

Updated: Jun 16, 2025

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

29.5K

生物分子凝聚物控制并由病毒复制中产生的RNA-RNA相互作用定义

Christine Roden, Dilimulati Aierken, Vita Zhang

    Research square
    |June 5, 2025
    PubMed
    概括

    细胞使用生物分子凝聚剂来管理RNA-RNA相互作用,防止纠. 在这些凝聚物中的SARS-CoV-2RNA相互作用会影响它们的结构,保持病毒复制效率.

    更多相关视频

    Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures08:02

    Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

    Published on: May 31, 2024

    720
    Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution10:53

    Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution

    Published on: January 16, 2017

    9.0K

    相关概念视频

    Retrovirus Life Cycles01:10

    Retrovirus Life Cycles

    Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
    45.8K
    Nucleic Acid Structure01:25

    Nucleic Acid Structure

    The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
    DNA Structure
    DNA...
    6.1K
    Viral Mutations00:36

    Viral Mutations

    A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
    32.2K
    Nucleic Acids02:43

    Nucleic Acids

    Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
    DNA and RNA
    The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
    44.0K
    siRNA - Small Interfering RNAs02:30

    siRNA - Small Interfering RNAs

    Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
    In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
    16.7K
    What are Viruses?00:50

    What are Viruses?

    Overview
    114.4K