探索不同长期抗逆转录病毒策略的偏好,担忧和实施,以帮助艾滋病毒感染者面临坚持挑战的青少年
Ashle Barfield1, Elise Tirza Ohene-Kyei1,2, Raina Smith2
1Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
AIDS patient care and STDs
|June 5, 2025
概括
携带艾滋病毒 (YHIV) 的年轻人表示愿意使用长效抗逆转录病毒治疗 (LA-ART) 选择,包括注射和药丸. 偏好倾向于较少的剂量和特定的注射部位,这表明改善粘附的潜力.
科学领域:
- * 艾滋病毒/艾滋病研究
- * 青少年和年轻人的健康
- * 药理学和药物输送系统
背景情况:
- *13-25岁的人类免疫缺陷病毒 (YHIV) 感染的年轻人面临着坚持每天口服抗逆转录病毒治疗 (ART) 的挑战.
- * 长效抗逆转录病毒治疗 (LA-ART) 提供了一种潜在的解决方案,以改善坚持和长期健康结果.
- *了解YHIV对LA-ART的偏好对于成功实施至关重要.
研究的目的:
- * 探索YHIV使用各种长效ART (LA-ART) 输送策略的意愿.
- * 为了比较不同LA-ART配方的偏好,包括肌内注射,皮下注射,皮下植入物和LA-ART药片.
- * 确定可注射LA-ART的首选注射地点和剂量频率.
主要方法:
- * 一项采用电话调查的横截面试点研究.
- * 嵌入随机对照试验中的调查 (NCT03600103) 专注于YHIV的病毒抑制.
- *参与者 (N=19) 评估了他们对四种LA-ART替代品和每日口服ART的偏好.
主要成果:
- * 长效药丸是最喜欢的LA-ART方法 (84%).
- * 很愿意尝试注射LA-ART:79%用于肌内 (IM) 和皮下 (SC),74%用于皮下植入物 (SDI).
- *在选择一种方法时,IM被选为58%最合适的,手臂优先于大腿作为注射点. 随着注射频率的减少 (例如,每三个月,而不是每周一次),愿意度增加.
结论:
- * 患有坚持困难的YHIV对新的LA-ART输送方法持开放态度.
- *解决人们的担忧和教育YHIV关于LA-ART疗效,可以提高吸收率.
- *增加LA-ART的采用有潜力降低YHIV中不遵守率.
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