评估数字通信工具对口服PrEP遵守的影响:系统性审查和元分析
Julien Brisson1, Dorothy Apedaile2, Mariangela Castro-Arteaga3
1Social & Behavioural Health Sciences Division, Dalla Lana School of Public Health, University of Toronto, 155 College Street, 5 th Floor, Room 554, Toronto, ON, M5 T 3M7, Canada. j.brisson@utoronto.ca.
AIDS and behavior
|June 5, 2025
概括
像短信这样的数字工具在12周内适度改善了每日口服艾滋病毒暴露前预防 (PrEP) 的坚持,但效果没有持续. 对于长期遵守策略,需要进一步的研究.
科学领域:
- 公共卫生 公共卫生
- 数字健康数字健康
- 预防艾滋病毒 预防艾滋病毒
背景情况:
- 每日口服艾滋病毒暴露前预防 (PrEP) 对于预防艾滋病毒至关重要.
- 每天口服PrEP的坚持可能是具有挑战性的.
- 数字通信工具为改善遵守提供了潜在的解决方案.
研究的目的:
- 系统地审查和元分析数字沟通工具在改善日常口服PrEP遵守方面的有效性.
- 评估诸如短信和移动应用程序等干预措施对PrEP遵守的影响.
主要方法:
- 2012-2024年随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了主要的数据库 (PubMed,Embase,Web of Science,PsychInfo) 和临床试验注册表.
- 使用随机效应元分析汇集了十项RCT的数据,以估计适当遵守PrEP的风险比率.
主要成果:
- 数字干预显示,在12周后,PrEP的坚持程度略有改善 (RR=1.08).
- 在24周后,没有观察到对PrEP坚持的显著影响 (RR=1.10).
- 干预措施包括短信,移动应用程序和移动游戏,主要研究与男性发生性关系的男性 (MSM) 和跨性别女性 (TW).
结论:
- 数字通信工具对持续的每日口服PrEP坚持的影响有限.
- 目前的数字化策略可能不足以提供长期的坚持支持.
- 开发多样化和持续的干预策略是必要的,以改善PrEP的坚持.
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