相关实验视频
Updated: Feb 5, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
通过抑制STAT3,通过恢复Th17/Treg免疫平衡来缓解实验性自身免疫性胃炎
Aiqing Zhang1, Lingyun Niu1, Yahui Ni1
1Department of Gastroenterology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No 99, Longcheng Street, Taiyuan, 030032, Shanxi, China.
STAT3信号驱动自身免疫性胃炎 (AIG) 和转化成形. 在AIG小鼠模型中,通过STA-21抑制STAT3可减少炎症并恢复免疫平衡.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 自身免疫性胃炎 (AIG) 是一种影响胃的炎症性疾病.
- 信号转换器和转录3激活器 (STAT3) 在各种自身免疫性疾病中涉及.
研究的目的:
- 为了研究STAT3在AIG病变发生中的作用.
- 为了评估STA-21的治疗潜力,一个STAT3抑制剂,在AIG.
主要方法:
- 在Txa23小鼠中建立了AIG模型,并使用高剂量他莫西芬 (HDT) 诱导胃部变化.
- 用STA-21来评估STAT3抑制作用.
- 分析了胃组织的炎症,免疫细胞群 (Th17,Treg),细胞因子表达和转化成形标志物.
- 使用了H&E染色,免疫组织化学,流细胞计,qPCR和ELISA.
主要成果:
- 在AIG小鼠中,STAT3和酸化STAT3 (p-STAT3) 的上调,与炎症和转化等相关.
- 在STAT3淘汰的小鼠中,炎症和转化成形减少.
- STA-21治疗缓解了胃缩,减少了炎症,抑制了Th17细胞和增强了Treg细胞,恢复了Th17/Treg平衡.
结论:
- 在AIG的发病过程中,STAT3起着至关重要的作用.
- 通过STA-21抑制STAT3,通过调节免疫反应和减少转化成形来证明AIG的治疗潜力.
更多相关视频
08:47Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
09:01Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
相关概念视频
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Restorative Care
What is the Immune System?
Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Balancing Redox Equations
Feedback Inhibition