相关实验视频
Updated: Sep 19, 2025

04:08
Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
465
胎盘断裂和围产期死亡率:异常胎位和自发流产是导致左侧截断偏差的因素
Alan C Kinlaw1,2, Hillary L Graham3,4, Cande V Ananth4,5,6,7
1Division of Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA.
Paediatric and perinatal epidemiology
|June 5, 2025
概括
左切断偏差可能会低估围产期死亡率研究中的断裂风险,特别是在异常的胎盘. 考虑到早期怀孕事件对于产科中准确的因果推断至关重要.
科学领域:
- 围产期流行病学 围产期流行病学
- 生殖健康 生殖健康
- 生物统计学 生物统计学
背景情况:
- 研究往往不包括早期怀孕数据 (怀孕20周之前),可能导致左切断偏差.
- 暴露和与围产期死亡相关的结果可能发生在怀孕20周之前.
研究的目的:
- 评估左切断偏差如何影响对胎盘断裂对围产死亡率的因果影响的估计.
- 在异常胎盘的背景下调查这种偏见,使用自发性流产作为审查事件.
主要方法:
- 利用了80个蒙特卡洛模拟场景与现实的临床假设.
- 估计的风险差异 (RD) 和风险比率 (RR) 来量化断裂 - 产前死亡率的关联和偏差.
主要成果:
- 与怀孕队列相比,左切断数据 (≥20周) 低估了死亡风险.
- 在胎盘异常的怀孕中,偏差更为明显,RDs偏差为+5%至+43%.
- 由于对死亡率的差异性低估,对异常胎盘的风险比率 (RR) 被高估了1.1至8.4倍.
结论:
- 异常的胎盘显著增加了流产,胎盘断裂和并发症的风险.
- 左切断偏差扭曲了断裂与围产期死亡率的关联,随着胎盘正常变化而变化.
- 关于断裂死亡率的因果问题需要定义目标人群 (例如,所有受孕),并从结果跟踪中解决潜在的左切断偏差.
相关概念视频
Truncation in Survival Analysis
327
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
327
Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
Regression Toward the Mean
6.5K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.5K
Fetal Circulation
1.4K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.4K

