儿童癌症幸存者体质指数,身体活动和随后的新生体风险
Lenat Joffe1,2, Sedigheh Mirzaei3, Shalini Bhatia3
1Northwell, New Hyde Park, New York.
JAMA oncology
|June 5, 2025
概括
患有肥胖的儿童癌症幸存者面临更高的后续瘤风险,而增加体力活动提供了保护. 生活方式干预对于未来的预防策略至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 高体重指数 (BMI) 和低体力活动是已知的成人癌症的风险因素.
- 关于儿童癌症幸存者的BMI,体力活动和随后的瘤之间的关联存在有限的数据.
研究的目的:
- 调查时间变化的身体质量指数 (BMI) 和身体活动水平与儿童癌症幸存者的后续瘤发病风险之间的关系.
主要方法:
- 进行了儿童癌症幸存者研究 (CCSS) 中22,716名儿童癌症幸存者的回顾性队列分析.
- 自我报告的,随时间变化的BMI和体力活动 (MET-h/wk) 在诊断后被评估了多达六次.
- 统计模型估计了后续瘤的累积发病率和相对率 (RRs),经过对共变量进行调整.
主要成果:
- 肥胖与固体器官,中枢神经系统 (CNS) 和皮肤瘤的发病率增加有关.
- 较高的体力活动 (每周15-21MET-h) 与整体后续瘤以及固体器官,中枢神经系统和皮肤瘤的风险降低有关.
- 对于脑膜瘤和甲状腺癌发现了特定的关联,但对于乳腺,结肠直肠或血液瘤没有.
结论:
- 肥胖增加了儿童癌症幸存者的各种后续瘤的风险.
- 在这个人群中,较高的体力活动水平与随后瘤的风险降低有关.
- 未来的研究应该探索生活方式干预措施,以预防儿童癌症幸存者的后续瘤.
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