血管功能障碍与糖尿病前期的主要不良心血管事件有关:一个队列研究
Dariya Kozlova1, Colin Gimblet1, Linder Wendt2
1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
PloS one
|June 5, 2025
概括
糖尿病前期会增加心血管疾病的风险. 脑内皮功能受损,通过手臂动脉流量介导扩张来衡量,独立预测糖尿病前期患者的主要不良心血管事件.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 糖尿病前期是一个重要的公共卫生问题,与重大心血管不良事件 (MACE) 的风险增加有关.
- 由高血糖症加剧的血管功能障碍与高危人群中的MACE有关.
- 血管功能障碍对糖尿病前期MACE的具体贡献尚不清楚.
研究的目的:
- 为了研究血管功能障碍与糖尿病前期成人MACE风险之间的关联.
- 为了确定内皮功能,大动脉硬或冠状动脉化是否预测糖尿病前期的MACE.
主要方法:
- 一项观察性研究涉及来自弗雷明汉姆后代和第三代队伍的5742名成年人.
- 使用美国糖尿病协会 (ADA) 标准诊断出糖尿病前期.
- 通过手臂动脉流介导扩张 (BA-FMD),大动脉硬度的动脉-大腿脉冲波速 (cfPWV) 和冠状动脉 (CAC) 评分来评估血管功能.
主要成果:
- 与对照人群相比,糖尿病前期患者的BA-FMD得分较低,cfPWV和CAC得分较高.
- 在对传统心血管风险因素进行调整后,降低BA-FMD (HR 0.93; 95% CI [0.90,0.97]) 和升高的CAC得分>100 (HR 4.15; 95% CI [2.24,7.70]) 与MACE显著相关.
- 在这个队列中,关节-关节脉冲波速率 (cfPWV) 与MACE没有显著的关联.
结论:
- 血管功能障碍,特别是内皮功能受损 (BA-FMD),是糖尿病前期患者中MACE的独立预测因子.
- 通过治疗干预来准血管功能障碍可能是一个可行的策略,以减轻糖尿病前期患者心血管疾病 (CVD) 风险.
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