免疫和肠道微生物群的性别差异对军事训练的反应
Adrienne Hatch-McChesney1, Cassandra Suther, Lauren A Thompson1
1U.S. Army Research Institute of Environmental Medicine, Natick, MA.
Medicine and science in sports and exercise
|June 5, 2025
概括
军事训练会影响免疫功能和肠道细菌. 虽然两性都经历了压力反应,但与女性相比,男性的免疫功能下降更明显,肠道微生物群的变化更明显.
科学领域:
- 人类生理学 人类生理学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 军事训练带来了重要的生理压力.
- 这些压力因素可能会损害免疫功能并改变肠道微生物群的组成.
- 这些反应中潜在的性别差异尚未得到充分理解.
研究的目的:
- 在军事训练期间调查免疫和肠道微生物群反应.
- 为了确定这些生理适应的潜在的性别差异.
主要方法:
- 72名学员 (33%为女性) 接受了为期17天的军事训练.
- 免疫标记物 (唾液SIgA,病毒活性,白细胞,细胞因子) 和肠道微生物群 (16SrRNA测序) 在训练前和训练后被评估.
- 分析了数据的变化随着时间的推移和性别特异性差异.
主要成果:
- 训练诱导了所有参与者的体重减轻和增加压力激素 (皮质醇) 和细胞因子.
- 男性的粒细胞与淋巴细胞比率以及唾液SIgA的降低,与女性不同.
- 肠道微生物群显示出性别独立的变化,男性比女性的Bifidobacterium和Ruminococcus显著增加.
结论:
- 军事训练引发了显著的免疫再分配和肠道微生物群的变化.
- 这些变化与压力严重程度相关,并表现出明显的性别差异.
- 在艰苦的军事训练期间,男性似乎经历了更明显的免疫功能抑郁.
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