破坏瘤乳酸平衡以使化疗免疫疗法敏感,使用一种伪装成葡萄糖的乳酸拦截器
Xuwen Li1,2,3, Shuo Geng1,2,3, Qinjun Chen1,2,3
1Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
ACS nano
|June 5, 2025
概括
这项研究引入了一种新的策略,通过向乳酸运输来破坏瘤代谢共生. 通过拦截癌细胞内的乳酸,这种方法旨在克服化疗免疫疗法耐药性.
科学领域:
- 在瘤学瘤学.
- 癌症新陈代谢 癌症新陈代谢
- 免疫治疗是一种免疫疗法.
背景情况:
- 升高的乳酸流为瘤代谢共生,免疫抑制和化疗免疫疗法耐药性提供燃料.
- 单碳酸盐载体4 (MCT4) 对于高甘油性瘤中乳酸流出至关重要.
研究的目的:
- 开发一种策略,精确调节瘤细胞中的乳酸平衡.
- 以MCT4为目标,选择性地将调节分子送入癌细胞.
主要方法:
- 设计了一种伪装成葡萄糖的输送系统,以准依赖糖解的瘤细胞.
- 干预细胞内乳酸分子调节瘤细胞代谢.
主要成果:
- 该策略选择性地拦截瘤细胞中的细胞内乳酸.
- 瘤亚群和免疫细胞之间的乳酸介导交叉声中断.
- 在瘤微环境中克服了乳酸驱动的代谢合作.
结论:
- 这种方法有效调节乳酸平衡,破坏瘤代谢共生.
- 可能提供一种新的策略来克服与乳酸相关的化学免疫疗法耐药性.
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