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基于生物材料的治疗方法用于脊椎间盘退化的结构重建

Zongtai Liu¹, Qingzheng Zhang¹, Yuehong Li¹

¹Department of Spine Surgery, Center of Orthopedics, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, PR China; State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.

|June 5, 2025

概括

基于生物材料的疗法在治疗椎间盘退化 (IDD) 方面表现有前途,这是腰部疼痛的主要原因. 这些先进的方法旨在通过向关键的病理机制来再生受损的磁盘.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
整形外科整形外科整形外科

背景情况:

椎间盘退化 (IDD) 是一种普遍的疾病,导致腰部疼痛 (LBP) 和功能障碍.
目前对IDD的治疗方法在停止退行或恢复磁盘功能方面具有有限的有效性.
IDD显著影响患者的生活质量,并对医疗保健系统造成重大负担.

研究的目的:

审查基于生物材料的疗法在治疗椎间盘退化 (IDD) 的潜力.
探索生物材料如何解决IDD的关键病理机制,包括细胞损失和结构缺陷.
突出IDD的再生战略的进展.

主要方法:

文献综述侧重于生物材料在椎间盘 (IVD) 再生中的应用.
分析生物材料如何针对IDD的细胞和微环境方面.
检查基于生物材料的战略,用于退化的磁盘的结构重建.

主要成果:

基于生物材料的配方提供了在退化的磁盘中功能性细胞补充的潜力.
这些材料可以调节细胞外微环境,这对磁盘健康至关重要.
创新的生物材料显示了结构重建的能力,为IDD推进了再生疗法.

结论:

基于生物材料的疗法代表了治疗椎间盘退化 (IDD) 的前沿.
用先进的生物材料准病理机制可以阻止疾病的进展并促进再生.
对生物材料-IVD相互作用的进一步研究对于开发有效的再生疗法至关重要.

关键词:

生物材料是一种生物材料.细胞移植细胞移植有控制的药物输送.椎间盘退化椎间盘退化微环境法规微环境法规生理结构重建重建的物理结构.

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