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温度暴露对梅达卡 (Oryzias latipes) 大脑上热极限和线粒体功能的多代影响
Julie Morla1, Mélissa Richard1, Rémy Lassus1
1INRAE, Aix-Marseille Univ, UMR RECOVER, 3275 Route Cézanne, 13182, Aix-en-Provence, France.
Journal of thermal biology
|June 5, 2025
概括
多代暴露在更高的温度下,通过增加线粒体复合体II活动,改善了鱼的上热极限 (CTmax). 这表明线粒体功能与在气候变化中耐热性之间存在联系.
科学领域:
- 环境生理学环境生理学
- 线粒体生物学 线粒体生物学
- 适应气候变化 适应气候变化
背景情况:
- 生物体的热极限对于预测气候变化影响至关重要.
- 线粒体功能障碍与在临界热极限 (CTmax) 中神经肌肉功能丧失有关.
研究的目的:
- 调查线粒体功能障碍和CTmax之间的关系.
- 确定多代热暴露是否会改变CTmax和线粒体性能.
主要方法:
- 梅达卡鱼 (Oryzias latipes) 在恒定的20°C (冷) 或30°C (热) 中养了五年.
- 测量CTmax和线粒体氧耗率 (OCRs) 在25°C和CTmax.
- 测定线粒体复合体的呼吸控制比率 (RCR).
主要成果:
- 多代热暴露使CTmax增加了13%.
- 所有鱼类的复合I的OCR和RCR从25°C下降到CTmax.
- 线粒体复合体II对OCRs的贡献在高温下增加.
结论:
- 整个生物体的热耐受性与线粒体的性能和功能障碍有关.
- 多代暴露可以提高线粒体和热性能.
- 复合II可能在线粒体适应高温方面发挥关键作用.
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