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Updated: Sep 19, 2025

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples

Published on: May 10, 2015

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杜比基因酶USP7稳定了HER2的表达,并促进了乳腺癌的进展

Xiaoyue He1, Xiaohong Xia2, Ziying Lei2

  • 1Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou 510095, PR China; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China.

Neoplasia (New York, N.Y.)
|June 5, 2025
PubMed
概括

研究人员发现USP7二维基因酶 (DUB) 在HER2阳性乳腺癌中稳定HER2蛋白. 抑制USP7降低了HER2水平,减缓了癌症生长,并建议USP7作为潜在的治疗点.

关键词:
增长的增长 增长的增长在HER2阳性乳腺癌.USP7 USP7 美国在Ubiquitination中使用.

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