低出生体重与质发育缺陷的关联:系统性审查与元分析
Eugênia Lívia de Andrade Dantas1, Basílio Rodrigues Vieira2, Bianca Marques Santiago3
1Graduate Program in Dentistry, Health Sciences Center, Federal University of Paraíba, Paraiba, Brazil.
Archives of oral biology
|June 5, 2025
概括
低出生体重 (LBW) 与落叶牙 (DDE) 发育缺陷有因果关系,但不是永久牙. 这项研究使用了生理模型来证实母牙中的LBW-DDE关联.
科学领域:
- 牙科公共卫生 牙科公共卫生
- 儿科牙科 儿科牙科
- 发展生物学 发展生物学
背景情况:
- 低出生体重 (LBW) 是已知的乳液发育缺陷 (DDE) 的风险因素.
- 病因生理 (Eti-Phys) 模型为理解DDE发育提供了一个框架.
- 之前的研究并没有使用该模型严格测试LBW和DDE之间的关联.
研究的目的:
- 为了研究LBW和DDE/切虫低矿化 (MIH) 在落叶和永久牙之间的关联.
- 将观察到的DDE风险与Eti-Phys模型预测的风险进行比较.
主要方法:
- 进行了对横截面,队列和病例控制研究的系统审查和元分析.
- 搜索包括主要数据库 (PubMed,科学网,LILACS,SCOPUS,Embase) 和灰色文献,截至2024年4月.
- 进行了随机效应元分析,并对DDE风险进行了子组分析.
主要成果:
- 其中包括60篇文章. 观察到的和基于模型的DDE风险存在显著的相关性 (p < 0.001).
- LBW显示了与叶落牙的DDE有显著的关联 (RR=1.76) 和甚至更强的hypoplasia (RR=3.30),特别是非常LBW.
- 在永久牙中,LBW和DDE之间没有发现显著的关联 (p=0.49). 关于LBW和MIH的数据有限.
结论:
- Eti-Phys模型支持LBW和DDE之间的因果关系.
- 在永久牙中,LBW和DDE之间的关联并不明显.
- 需要进一步的研究来澄清LBW和MIH之间的关系.
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