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亚洲 Pseudomonas 的基因组表征作为乳牛中新兴的乳腺炎病原体,具有耐药性和毒性影响

Taniya Sultana¹, Md Morshedur Rahman¹, Monira Rahaman¹

¹Molecular Biology and Bioinformatics Laboratory, Department of Gynecology, Obstetrics and Reproductive Health, Gazipur Agricultural University, Gazipur, Bangladesh.

Journal of global antimicrobial resistance

|June 5, 2025

概括

亚洲性牛是一种新兴的多药耐药性 (MDR) 乳腺炎病原体,在奶牛及其环境中发现. 这项研究详细介绍了其流行率,耐药性基因和毒性因素,强调了针对性控制策略的必要性.

科学领域:

兽医微生物学兽医微生物学
抗微生物耐药性抗微生物耐药性
乳制品科学乳制品科学

背景情况:

乳腺炎是乳制品行业的重要经济和动物福利问题.
多药耐药 (MDR) 病原体使乳腺炎治疗复杂化.
亚洲性伪虫越来越多地被认为是潜在的乳腺炎致病剂.

研究的目的:

为了确定Pseudomonas asiatica在临床乳腺炎 (CM) 的奶牛中的流行率.
鉴定P. asiatica孤立菌株的抗微生物耐药性 (AMR),抗生素耐药性基因 (ARG) 和病毒性基因 (VG).
了解P. asiatica. 的遗传关系和环境持久性.

主要方法:

从孟加拉国的乳制品农场的牛奶,便和土壤收集样本.
使用培养物,VITEK-2和16S rRNA测序来识别P. asiatica.
通过光盘扩散进行抗微生物敏感性测试.
全基因组测序 (WGS) 用于对MDR分离物的遗传学,ARG和VG分析.

主要成果:

在牛奶,便和土壤样本中,P. asiatica的流行率为37.27%.
所有的分离物都是MDR,对多种抗生素具有很高的耐药性,包括伊米和亚齐菌素.
WGS证实了与全球菌株的遗传链接,并确定了每个隔离物11个ARG和30个VG.

结论:

亚洲性 Pseudomonas是一种新兴的MDR乳腺炎病原体,具有环境持久性.
研究结果强调,需要为有效的乳腺炎管理提供特定物种的诊断.
量身定制的抗微生物策略对于在奶牛养殖中控制P. asiatica至关重要.

关键词:

临床乳腺炎是一种临床乳腺炎.奶牛牛奶牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛牛农场土壤农场土壤便便便便牛奶牛奶牛奶牛奶亚洲的P. 亚洲的人类的家谱 (Phylogeny) 是一个学科.电阻电阻电阻电阻电阻电阻病毒性病毒性

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