大麻使用和心房律不整:对大型人口研究的系统审查和元分析
David M Chye1, Thalys Sampaio Rodrigues2, Levindo J G Quarto3
1Department of Cardiology, Austin Health, Melbourne, Australia; Department of General Medicine, Austin Health, Melbourne, Australia.
Heart rhythm
|June 5, 2025
概括
大麻使用与71%更高的心房律乱 (AA) 风险有关. 需要进一步的研究,特别是在非西方和青少年人群中,以告知大麻和心脏健康的公共卫生和合法化政策.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 众所周知,含有Delta-9-tetrahydrocannabinol的大麻会影响心血管健康,导致交感刺激和内皮功能障碍.
- 现有研究强调大麻的心血管风险,但对心房失常 (AA) 的数据有限.
- 大心律不整包括诸如心房动,动和心跳动等情况,以及心跳动.
研究的目的:
- 调查大麻使用与发展心房失常症的风险之间的关联.
- 综合观察性研究的证据来量化风险.
主要方法:
- 在MEDLINE,Embase和Cochrane控制试验中央注册表中进行了系统的文献搜索,直到2024年4月.
- 包含超过8100万参与者的14项观察性研究被纳入了元分析.
- 使用随机效应模型将几率比率 (OR) 和95%置信区间 (CI) 用于大麻使用和AA之间的关联.
主要成果:
- 大麻使用与心房律乱风险显著增加71%相关 (OR 1.71,95% CI 1.1-2.6,P = .01).
- 在12.5%的大麻使用者中观察到心房失常,而非使用者中则为2.7%.
- 在大麻合法国家的同时使用毒品和大麻消费与AAs的风险进一步增加有关 (分别为OR 1.91和1.93).
结论:
- 大麻使用显著与心房失常风险的增加有关.
- 关于大麻使用和非西方人口和青少年的AAs的研究显著缺乏.
- 未来的研究应该集中在这些代表性不足的群体上,以告知公共卫生战略和大麻合法化政策.
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