在纤维肌痛和阿片类药物使用中降低了梯形压力疼痛值
Carina Lei1, Su Hyoun Park2, Edna J Evington1
1Human Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA.
The journal of pain
|June 5, 2025
概括
与未服用阿片类药物的患者相比,长期使用阿片类药物并没有显著改变纤维肌痛患者的疼痛敏感性. 然而,最近的阿片类药物剂量可能会暂时增加长期使用者的疼痛值.
科学领域:
- 疼痛研究 疼痛研究
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物是有效的止痛药,但可以矛盾地增加疼痛敏感性 (阿片类药物诱导的过敏症).
- 关于长期阿片类药物对慢性疼痛症状疼痛敏感性的影响的研究是有限的.
研究的目的:
- 研究长期阿片类药物对纤维肌痛患者疼痛敏感性的影响.
- 为了比较长期服用阿片类药物的纤维肌痛患者,非阿片类药物的患者和无疼痛对照者的疼痛敏感性.
主要方法:
- 在三个组中测量压力疼痛值 (PPT):无疼痛对照组,没有阿片类药物的纤维肌痛 (FMN) 和长期使用阿片类药物的纤维肌痛 (FMO).
- 评估抑郁症 (BSI-18) 和疲劳 (PROMIS) 以探索与疼痛敏感性的相关性.
- 使用共变量和灵敏度分析控制年龄,种族,种族和BMI.
主要成果:
- 与对照组相比,FMN和FMO两组的PPT显著减少.
- 在FMO和FMN组之间没有发现PPT的显著差异.
- 在纤维肌痛组中,抑郁和疲劳与PPT没有显著的相关性.
- 在FMO组中,最近的阿片类药物剂量与更高的PPT (疼痛敏感性降低) 有关.
结论:
- 压力疼痛值降低是纤维肌痛的特征,无论长期使用阿片类药物.
- 阿片类药物剂量计时的短期影响可能会影响长期阿片类药物使用者患有纤维肌痛的疼痛敏感性.
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