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Updated: Jun 13, 2025

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy
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Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy

Published on: May 4, 2016

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发展中的视网膜通过PINK1/PRKN依赖的线粒细胞衰变 (mitophagy) 经历线粒体重塑

Juan Zapata-Muñoz1, Juan Ignacio Jiménez-Loygorri2, Michael Stumpe3

  • 1Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee DD1 5EH, UK.

Journal of molecular biology
|June 5, 2025
PubMed
概括

这项研究揭示了视网膜发育期间的两个关键的线粒峰,一个与视网膜质细胞相关,另一个通过PINK1.1与氧化应激相关. 这突出了在发育过程中编程的线粒体清除.

关键词:
标签:PINK1PINK1PINK1PINK1自自是自的过程.发展发展发展发展发展.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.视网膜 视网膜 视网膜 是一个

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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
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Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
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