基于成像的瘦体质量分布和美国人口中的糖尿病病
Xiaoqian Zhang1, Bin Han2, Weijie Yuan1
1Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Diabetes research and clinical practice
|June 5, 2025
概括
瘦体质量分布,特别是较高的Android瘦体质指数和Android-gynoid瘦体质量比,与美国糖尿病成年人糖尿病脏病的患病率有关.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 身体组成分析 身体成分分析
背景情况:
- 糖尿病病 (DN) 是糖尿病的一个主要并发症.
- 了解影响DN风险的因素对于预防和管理至关重要.
- 瘦体质量 (LBM) 的分布可能在DN发展中起作用.
研究的目的:
- 调查美国糖尿病人群中LBM分布和DN之间的关联.
- 探索区域性LBM与患糖尿病病的风险之间的关系.
主要方法:
- 使用NHANES数据 (2011-2018) 的横截面研究.
- 通过双能X射线吸收计 (DXA) 评估的身体组成.
- 采用多变量逻辑和线性回归分析.
主要成果:
- 增加的安卓瘦身质量指数 (LMI) 和安卓-骨瘦身质量比 (AGLR) 与更高的DN患病率有关,即使在调整后.
- 这些关联在男性中显著.
- 在AGLR和白蛋白与肌素比率 (ACR) 之间发现了正线性相关性.
结论:
- 较高的安卓LMI和AGLR与糖尿病患者的DN患病率有关.
- AGLR也与ACR显著相关,ACR是损伤的标志物.
- 瘦质量分布是评估DN风险的一个重要考虑因素.
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