前额叶皮质在慢性低背痛与并发性抑郁症中的作用:休息状态fMRI研究
Yanqiao Zhao1, Chen Gong2, Pan Zhu3
1Department of Rehabilitation Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Faculty of Health, Xuzhou Vocational College of Bioengineering, Xuzhou, China.
Brain research bulletin
|June 5, 2025
概括
抑郁症的慢性腰部疼痛 (CLBP) 在右脊侧前额皮层 (DLPFC) 显示出异常的大脑活动. 这些大脑变化与疼痛和抑郁症严重程度有关,为治疗提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 疼痛研究 疼痛研究
背景情况:
- 慢性腰部疼痛 (CLBP) 经常与抑郁症同时发生.
- 在伴随抑郁症的CLBP中,特定的中枢神经处理变化尚未得到充分理解.
研究的目的:
- 通过功能磁共振成像 (fMRI) 调查患有伴随性抑郁症的CLBP患者的大脑异常.
- 探索大脑活动变化,疼痛感知和抑郁症状之间的关系.
主要方法:
- 功能性MRI (fMRI) 用于在三个组中检查区域同质性 (ReHo) 和功能连接性 (FC):患有抑郁症的CLBP,没有抑郁症的CLBP和健康对照.
- 统计分析包括ANOVA,后期测试,相关性分析和中介分析.
主要成果:
- 在大脑广泛区域观察到ReHo的显著差异,特别是在右背侧前额叶皮层 (DLPFC).
- 在DLPFC和小脑,以及轨道前皮层之间发现了改变的FC.
- ReHo和FC值与抑郁症严重程度,疼痛灾难化和背部疼痛残疾相关.
结论:
- 伴随性抑郁症的CLBP患者在DLPFC中表现出异常的ReHo,以及涉及DLPFC的功能网络发生变化.
- 这些中枢神经变化与临床结果有关,并调解疼痛和抑郁之间的关系.
- 这些发现可能有助于识别抑郁症耐火性CLBP的生物标志物,有助于个性化疼痛管理策略.
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