SARM1激活会诱导可逆的线粒体功能障碍,在人类神经元中可以通过反感性寡核酸来预防

Andrea Loreto¹, Kaitlyn M L Cramb², Lucy A McDermott³+12

• ¹Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Save Sight Institute, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Oxford Parkinson's Disease Centre and Department of Physiology, Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, CB2 0PY Cambridge, UK.+8