系统审查和对肠道蛋白质摄入对早产婴儿生长的影响的元分析
Maria Sanchez-Holgado1, Mark J Johnson2,3,4, Ariadna Witte Castro1
1Department of Neonatology. La Paz University Hospital. Hospital La Paz Institute for Health Research-IdIPAZ, Madrid, Spain.
Pediatric research
|June 5, 2025
概括
早产婴儿的最佳蛋白质摄入对于生长至关重要. 这项审查发现,较高的蛋白质摄入量显著改善了非常早产婴儿的体重和长度增加.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 婴儿的成长和发展.
背景情况:
- 对于早产婴儿充分生长的最佳肠道蛋白质摄入量尚未得到充分确立.
- 本系统性审查的重点是强化母乳中的蛋白质摄入量对非常早产婴儿的生长的影响.
研究的目的:
- 评估肠道蛋白质摄入量对非常早产婴儿生长结果的影响.
- 确定最佳的蛋白质摄入量,以实现早产婴儿子宫内生长率.
主要方法:
- 随机临床试验的系统审查和元分析 (2005年1月 - 2024年8月).
- 包括的研究测量了早产婴儿的真实肠道蛋白质摄入量.
- 偏差风险使用修订后的Cochrane风险偏差工具进行评估.
主要成果:
- 在蛋白质摄入量和体重增加之间观察到显著的线性关系 (p=0.001).
- 更高的蛋白质摄入量与更高的出院体重 (SMD 0.35) 和更好的长度增长 (SMD 0.5) 相联系.
- 超回归表明,最佳生长需要4.0-4.5g/kg/天,超过目前的建议.
结论:
- 中等到高确定性证据表明,增加肠道蛋白质摄入量可以提高非常早产婴儿的生长结果.
- 足够的蛋白质摄入量对于实现最佳生长和排泄体重至关重要.
- 保持适当的能量:蛋白质比例对于早产婴儿营养至关重要.
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