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压缩疗法用于预防化疗诱导的外围神经病变的元分析

Feifei Hu¹, Fang Wang², Yao Ming¹

¹School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

|June 5, 2025

概括

压缩疗法显著降低了化疗诱导的周围神经病变 (CIPN) 的风险,这是帕克利塔塞尔的常见副作用. 这种干预在预防癌症治疗期间的神经损伤方面是安全有效的.

科学领域:

在瘤学瘤学.
神经学神经学
临床试验临床试验

背景情况:

化疗诱导的周围神经病变 (CIPN) 是癌症治疗的削弱性副作用,特别是使用像帕克利塔塞尔这样的药物.
目前对CIPN的管理策略有限,需要探索预防性干预措施.

研究的目的:

评估压缩治疗在预防化疗诱导的周围神经病变 (CIPN) 中的预防疗效.
评估压缩治疗对接受化疗的患者感觉和运动神经功能的影响.

主要方法:

进行了系统的元分析,包括随机对照试验 (RCT) 和准实验性研究.
从七项涉及533名接受基于帕克利塔塞尔的化疗治疗的参与者的研究中收集的数据.
主要结局包括临床显著的CIPN发生率,按神经类型分层,次要结局是CIPNAT分数和安全性.

主要成果:

压缩疗法显著降低了临床显著CIPN的总体发病率 (RR = 0.59).
对感觉神经 (RR = 0.33) 和运动神经 (RR = 0.38) 均观察到预防作用.
压缩疗法与改善的CIPNAT分数 (MD = -36.16) 相联系,并且表现出良好的安全性概况与罕见的不良事件.

结论:

压缩疗法显示出显著的希望,作为帕克利塔塞尔诱导的CIPN.的预防性干预.
该疗法在临床上是安全的,并且有效地减少神经病变的发生.
建议进一步进行高质量的随机对照试验,以验证这些发现并建立标准化指南.

关键词:

化疗化疗是一种化学疗法.压缩疗法是一种压缩疗法.进行元分析分析.周围神经病变是一种神经病变.预防预防预防

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