头发皮质醇度升高与使用匹兹堡睡眠质量指数评估的睡眠质量差有关,但不与动图学相关
David S Michaud1, Mireille Guay2
1Health Canada, Non-Ionizing Radiation Health Sciences Division, Ottawa, Canada.
Journal of sleep research
|June 6, 2025
概括
头发皮质醇水平较高与自我报告的睡眠质量较差相关,表明头发皮质醇是慢性压力和睡眠障碍的有用生物标志物. 客观睡眠测量没有显示出显著的关联.
科学领域:
- 内分泌学和睡眠科学 睡眠科学
- 心理神经内分泌学心理学
- 生物标志物研究 生物标志物研究
背景情况:
- 慢性压力和睡眠障碍与不良健康结果有关.
- 头发皮质醇提供了对90天的皮质醇暴露的回顾性测量.
- 了解压力生物标志物与睡眠之间的关系对于公共健康至关重要.
研究的目的:
- 调查头发皮质醇度与主观和客观睡眠测量之间的关联.
- 评估毛皮质醇作为与睡眠障碍相关的慢性压力的生物标志物.
- 探索自我报告和客观测量的睡眠质量之间的潜在差异.
主要方法:
- 一项涉及483名成年人 (306名女性,177名男性;年龄在18-79岁之间) 的横截面研究.
- 从近接头发段分析的头发皮质醇度.
- 睡眠质量使用匹兹堡睡眠质量指数 (PSQI) 和动图学衍生的指标 (睡眠延迟,总睡眠时间,入睡后醒来,睡眠效率,唤醒发作) 进行评估.
主要成果:
- 头发皮质醇度较高与自我报告的睡眠质量较差 (PSQI > 5; p=0.020) 有显著的关联.
- 增加的PSQI平均得分也与较高的皮质醇水平相关 (p=0.027).
- 发皮质醇和动图学衍生的客观睡眠指标之间没有发现显著的关联.
结论:
- 毛皮质醇是一种有前途的生物标志物,用于评估与自我报告的睡眠障碍相关的慢性压力.
- 调查结果强调了对生物标志物和自我报告结果评估的时间框架进行调整的重要性.
- 需要进一步的研究来协调主观和客观的睡眠测量差异,并了解它们的生物学基础.
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