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开发基于α-桑托尼的新型氧化衍生物,作为潜在的杀虫剂候选剂

Ruige Yang^1,2, Meiyue Han², Caiwen Wu¹

¹Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.

Journal of agricultural and food chemistry

|June 6, 2025

概括

新的α-桑托宁衍生氧醇对农业害虫如Mythimna separata和Plutella xylostella表现出强大的杀虫活性. 这些新型绿色杀虫剂候选物对非标生物具有较低的毒性,提供了有前途的农业化学应用.

科学领域:

农业化学研究农业化学研究.
自然产品化学自然产品化学
昆虫毒理学昆虫毒理学

背景情况:

一种天然产品α-桑托宁在历史上曾被用作杀虫剂,但农业化学应用有限.
自然产品的结构优化对于开发新农药至关重要.
农业需要有效的低毒性杀虫剂.

研究的目的:

设计和合成基于α-桑托尼的新型氧化衍生物.
评估这些衍生品对关键农业害虫的杀虫作用.
为了探索初步的杀虫剂作用机制.

主要方法:

基于α-santonin的氧沙衍生物的化学合成.
对抗Mythimna separata,Myzus persicae和Plutella xylostella的杀虫剂,杀虫剂和虫剂活动的生物测试.
温室效应试验. 温室效应试验. 温室效应试验. 温室效应试验. 温室效应试验.
涉及酶抑制 (氨酸S转移酶) 和分子对接的初步机制研究.

主要成果:

化合物VII14对Mythimna separata (96.3%的纠正死亡率) 具有很高的疗效.
一些衍生品 (VII2,VII5,VII13,VII14,VII16) 显示出与罗诺相比,对Myzus persicae的杀虫活性更强.
化合物VII19和VII20对Plutella xylostella表现出强烈的幼虫杀伤活性,表现优于罗.
温室研究证实了VII19和VII20的强烈杀虫活性.
在Plutella xylostella中,VII19对谷氨S转移酶表现出抑制作用,受分子对接的支持.
活性衍生物对非标水生生物具有良好的安全性.

结论:

基于α-santonin的新型氧化衍生物具有显著的杀虫潜力.
这些化合物代表了开发高效和低毒性的绿色杀虫剂的有希望的候选者.
该研究为进一步开发和应用这些衍生物在农业化学品中的基础.

关键词:

控制有效性的有效性谷氨酸S转移酶是一种S转移酶.杀虫活动杀虫活动分子对接的分子对接.毒性的毒性毒性的毒性这是一种α-桑托宁衍生物.

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