Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.4K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Vertical-flow porous microchamber arrays for cell capture, intracellular molecule staining, and population analysis.

RSC advances·2026
Same author

Constriction-induced capture of rare cells using interdigitated microchannels with bidirectionally perforated thin honeycomb films.

Talanta·2025
Same author

Enhancing cancer cell immunocapture on orientation-controlled nanoimprinted microcone arrays in microgap channels.

Lab on a chip·2025
Same author

Designing Porosity-Tailored Hydrogel Sponges with Controlled Cell Positioning Using Dispersible, Autofragmented Sacrificial Microfibers.

ACS omega·2025
Same author

High-Density Microporous Drainage-Integrating Sheath Flow Generator for Streamlining Microfluidic Cell Sorting Systems.

Analytical chemistry·2024
Same author

bFGF-releasing biodegradable nanoparticles for effectively engrafting transplanted hepatocyte sheet.

Journal of controlled release : official journal of the Controlled Release Society·2023

相关实验视频

Updated: Jan 18, 2026

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

929

工程抗收缩3D细胞组件使用微型喷嘴生成的碎片化原蛋白微纤维.

Keigo Yamanaka1, Yuri Shimoda1, Rina Nonogaki1

  • 1Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Chiba, Japan.

Journal of biomaterials science. Polymer edition
|June 6, 2025
PubMed
概括

研究人员开发了一种高通量方法,用于制造碎片化原微纤维 (F-CMF) 用于组织工程. 这些微纤维能够制造先进的3D组织模型,改善细胞生长的氧气和营养供应.

关键词:
原蛋白是一种原蛋白.纤维细胞细胞是什么?微纤维纤维是一种微纤维.皮肤组织模型模型组织工程是组织工程.

更多相关视频

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

2.8K
Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

11.3K

相关实验视频

Last Updated: Jan 18, 2026

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

929
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

2.8K
Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
12:13

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

Published on: October 28, 2013

11.3K

科学领域:

  • 生物材料工程 生物材料工程
  • 组织工程是组织工程.
  • 细胞生物学 细胞生物学

背景情况:

  • 三维 (3D) 细胞培养对于组织工程,再生医学和体外药物测试至关重要.
  • 生物活性聚合物基板有可能改善工程组织中的氧气和营养供应.
  • 目前生产高吞吐量细胞大小材料的方法有限.

研究的目的:

  • 开发一种简单多功能的战略,用于高吞吐量生产碎片化原纤维 (F-CMF).
  • 通过凝剂成分,可以精确控制F-CMF形态.
  • 展示F-CMF在制造先进的3D组织模型中的应用.

主要方法:

  • 在F-CMF生产中,微型喷嘴辅助挤出与动诱导的剪切力相结合.
  • 控制I型原凝剂的组成 (聚和加厚剂度).
  • 制造皮肤和多层人体皮肤组织模型.

主要成果:

  • 高通量生产可调整形态的碎片化原微纤维 (F-CMFs).
  • 在皮肤组织模型中,F-CMFs有效抑制了细胞驱动的组织收缩.
  • 在微通道室中成功形成多层人类皮肤模型.

结论:

  • 拟议的方法为生产用于各种组织工程应用的F-CMF提供了一种新的方法.
  • 这种技术可以精确控制组织形状,并增强细胞矩阵相互作用.
  • 开发的F-CMF有望用于创建具有改进细胞功能的先进3D组织模型.