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Updated: Feb 13, 2026

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甘基林缺乏重新编程肝脏内葡萄糖和脂质代谢,延迟肝脏再生

Yitian Liu1, Yiwei Sun1,2, Lv Jin1

  • 1International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/Naval Medical University, Shanghai 200438, China.

Acta biochimica et biophysica Sinica
|June 6, 2025
PubMed
概括

甘基林通过FOXO1通路调节糖原分解和脂肪酸吸收,促进肝脏再生. 甘基林缺乏会损害肝脏的再生,突出其在代谢适应和肝细胞增殖中的关键作用.

关键词:
这就是FOXO1的意义.甘基林 (Gankyrin) 是一种天然的药物.脂肪酸吸收的时间糖原溶解 (glycogenolysis) 是一种肝脏再生 肝脏再生

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