在"我们所有人"研究计划中研究大麻使用与精神分裂症之间的多基因关系
Isabelle Austin-Zimmerman1, Hayley Ha Thorpe2, John J Meredith3
1Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
medRxiv : the preprint server for health sciences
|June 6, 2025
概括
对大麻使用障碍的遗传责任与精神分裂症有关,即使在没有大麻使用史的人中也是如此. 这凸显了将大麻使用遗传因素纳入精神分裂症研究的必要性.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 几十年的研究表明,大麻大量使用与精神分裂症之间存在强烈的关联.
- 遗传因素是相关的,但研究往往缺乏关于同一个体中两种表型的数据,导致混.
- 我们所有人研究计划提供多模式数据,包括关于精神分裂症和大麻使用的遗传和表型信息.
研究的目的:
- 研究大麻使用障碍和精神分裂症之间的遗传关系.
- 通过分析个体内的两种表型来解决未测量的混问题.
- 利用来自"我们所有人"研究计划的多模式数据.
主要方法:
- 测试了大麻使用障碍 (CUD) 和精神分裂症多基因分数 (PGS) 与大量大麻使用和精神分裂症之间的关联.
- 包括CUD和精神分裂症PGS作为联合预测因素.
- 使用宽松,严格和双重并发症标准定义病例状态.
主要成果:
- CUD和精神分裂症多原性责任独立地与大量大麻使用有关.
- 精神分裂症和CUD PGS都与精神分裂症独立相关.
- 对CUD的多基因责任与精神分裂症有关,即使在没有大麻使用记录的个人中,也与精神分裂症有关,这表明了性.
结论:
- 调查结果强调需要综合性模型,将大量大麻使用在精神分裂症病因学的遗传风险因素纳入其中.
- 大麻使用障碍遗传责任与精神分裂症有显著的关联.
- 性可能解释了CUD遗传责任和精神分裂症之间的关联.
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