多发性硬化症和相关疾病患者的长期COVID:一个多中心的横截面研究
Chen Hu1, Jiyeon Son2, Lindsay McAlpine3
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
medRxiv : the preprint server for health sciences
|June 6, 2025
概括
患有多发性硬化症和相关疾病 (pwMSRD) 的人长期COVID的几率更高,特别是症状恶化. 长期COVID显著影响pwMSRD的功能和残疾.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在患有多发性硬化症和相关疾病 (pwMSRD) 的人群中,管理长期的COVID会因为重叠的症状而面临挑战.
- 关于长期COVID易感性及其对pwMSRD的影响,存在证据差距.
研究的目的:
- 与对照组相比,评估pwMSRD中的长期COVID易感性.
- 在pwMSRD中评估长期COVID与多域功能和残疾的关联.
主要方法:
- 一个多中心的横截面研究,涉及969个pwMSRD和1003个对照.
- 参与者完成了71个感染后症状的调查;长期COVID根据2024年NASEM标准定义.
- 使用后勤,线性和波桑回归分析来评估赔率和关联.
主要成果:
- 在PwMSRD中,长期COVID的几率更高 (aOR=1.6),症状恶化的相关性更强 (aOR=2.3).
- 长期的COVID与身体功能,认知能力差,以及两组人群中抑郁症增加有关.
- 患有长期COVID的PwMSRD经历了更大的功能衰退,抑郁症恶化和更快的残疾进展.
结论:
- PwMSRD表明对长期COVID的易感性增加,特别是由于症状恶化.
- 长期的COVID加剧了pwMSRD的功能衰退和残疾进展.
- 早期识别和长期COVID的管理对于pwMSRD至关重要.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K
01:20COPD: Pathogenesis and Clinical Features
544
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
544
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K
01:22Chronic Obstructive Pulmonary Disease
1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.1K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
71
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
71