在厄瓜多尔西北部的环境暴露和人类肠道抵抗性
Irmarie Cotto1, Ana Durán-Viseras2, Kelsey J Jesser1
1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
medRxiv : the preprint server for health sciences
|June 6, 2025
概括
改善水,环境卫生和卫生 (WASH) 和减少动物暴露可能会降低肠道微生物群中的抗菌素耐药性 (AMR). 然而,这些因素也可能降低肠道微生物的多样性,特别是在儿童中.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 不足够的水,环境卫生和卫生 (WASH) 与增加对抗菌素耐药性 (AMR) 的暴露有关.
- 人与动物的密切互动和牲畜中不受管制的抗生素使用有助于耐药细菌的传播.
研究的目的:
- 评估动物暴露和WASH条件对厄瓜多尔孕妇和儿童肠道微生物群和抗体的影响.
- 确定与抗微生物耐药性基因 (ARG) 相关的特定WASH基础设施和动物相互作用因素.
主要方法:
- 利用了来自53名孕妇和84名儿童的元基因组测序数据.
- 采用多变量模型来分析环境因素,动物暴露和肠道抗体/微生物组之间的关系.
- 量化了抗微生物耐药性基因 (ARG) 和细菌种群的丰富性和多样性.
主要成果:
- 在所有参与者中检测到临床相关的ARG,包括来自*大肠杆菌*和*肺炎菌*的ARG,儿童的患病率更高.
- 在母亲身上,动物暴露的增加趋向于更独特的ARG,但与更大的肠道微生物多样性有关.
- 改善了母亲的WASH基础设施 (下水道/污水处理系统,管道水) 与较少的独特ARG和较低的ARG总丰度以及更长的饮用水接入时间有关.
结论:
- 改善WASH基础设施和管理动物暴露是减少AMR的潜在策略.
- 这些干预措施可能会影响肠道微生物组合,可能会减少分类学多样性.
- 环境因素和抗体之间的关联在儿童中不那么明显,这可能是由于幼儿微生物组的动态性.
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