在男性HPV感染研究中,酒精消费与门人类乳头瘤病毒之间的关联
Sherissa Mohammed-Ali1, Victoria Umutoni2, Matthew B Schabath3
1Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
medRxiv : the preprint server for health sciences
|June 6, 2025
概括
酒精消费与男性门人类乳头瘤病毒 (HPV) 患病率或发病率没有显著的关联. 然而,吸酒量较高的前吸烟者显示高风险HPV患病率增加.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 病毒瘤学 病毒瘤学
背景情况:
- 人类乳头瘤病毒 (HPV) 是门癌的已知危险因素.
- 了解影响HPV感染的因素对于预防策略至关重要.
研究的目的:
- 调查酒精消费与男性门HPV的流行率和发病率之间的关联.
- 探索与吸烟状态和性取向的潜在相互作用.
主要方法:
- 在男性HPV研究中,有1919名没有艾滋病毒的男性被录取.
- 门HPV患病率和发病率使用已知的方法来确定.
- 使用Poisson和逻辑回归模型量化和分析酒精消费,按吸烟状况和性取向分层.
主要成果:
- 总的来说,酒精消费与门HPV流行或发病率没有显著的关联.
- 当前吸烟者饮酒6天以上/月,高风险HPV患病率有所降低.
- 前吸烟者每月3-5天或每月6天以上饮酒,呈现出高风险HPV患病率的增加.
结论:
- 前吸烟者饮酒量较高与门HPV患病率增加有关.
- 酒精的炎症作用可能有助于HPV在这个群体的推广.
- 需要进一步的研究来澄清酒精在前吸烟者门HPV中的作用.
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