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在糖尿病前期和2型糖尿病患者中,与循环氨基酶1的升高相关的高血糖症
Muataz Jalil Hussein Al-Maliki1, Mostafa Allahyari1, Ahmad Abbasi2
1Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
在2型糖尿病和糖尿病前期患者中,氨基酸酶1 (ACY-1) 酶水平升高. 这些增加的ACY-1水平与关键的葡萄糖指标相关,这表明它在糖尿病进展中的作用.
科学领域:
- 生物化学 生物化学
- 代谢障碍 代谢障碍 代谢障碍
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 是一种普遍的代谢障碍,以高血糖和胰岛素抵抗为标志.
- 氨基酸代谢,包括分支链氨基酸代谢和葡萄糖生成,在糖尿病中显著改变.
- 氨基酸酶1 (ACY-1) 是一种对N-乙氨基酸水解至关重要的酶,释放自由氨基酸.
研究的目的:
- 在T2DM患者中研究循环中的氨基酶1 (ACY-1) 水平.
- 评估T2DM患者的ACY-1水平和血糖控制参数之间的相关性.
主要方法:
- 在30名T2DM患者,30名糖尿病前患者和30名对照组中,使用ELISA量化了血清ACY-1和胰岛素水平.
- 通过自动分析仪测量了禁食血糖 (FBS),2小时食后 (2hPP) 葡萄糖,HbA1c,尿素和肌素.
- 胰岛素耐药性是使用恒温模式评估胰岛素耐药性 (HOMA-IR) 公式来确定的.
主要成果:
- 与糖尿病前 (P=0.04) 和对照组 (P<0.0001) 相比,T2DM患者的血清ACY-1水平显著升高.
- 糖尿病前患者的ACY-1水平也高于对照组 (P=0.0093).
- ACY-1水平与FBS (R=0.453,P<0.00001) 和HbA1c (R=0.382,P=0.016) 有正相关,与胰岛素 (R=-0.263,P=0.014) 有负相关.
结论:
- 在T2DM和糖尿病前期均观察到血清ACY-1升高.
- ACY-1水平与关键的血糖指标相关,表明它可能参与2型糖尿病的发病和进展.
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