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Updated: Sep 19, 2025

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断裂诱导的复制被激活以修复SETX缺陷细胞中的R-循环相关的双链断裂

Tong Wu1, Youhang Li1, Linda Z Shi2

  • 1Department of Molecular and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037.

bioRxiv : the preprint server for biology
|June 6, 2025
PubMed
概括

缺陷的毒素 (SETX) 通过阻断由于RNA/DNA混合物的DNA合成,在双端双链断裂 (deDSBs) 上触发断裂诱导的复制 (BIR). 这揭示了BIR在修复deDSB中的新角色,并提出了新的癌症治疗策略.

关键词:
破坏诱导的复制 (BIR)在MRE11中,MRE11是MRE11中的一个.在PIF1中,PIF1是PIF1,PIF1是PIF1.这是一个R环.在RAD52中使用RAD52.参素 (SETX) 是一种在XPF中使用XPFXPF.双链断裂 (DSB) 是一种双链断裂.切除结束切除结束同类重组 (HR) 的方法.

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