Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects.

Regenerative biomaterials·2026
Same author

Conformational ensemble-guided hapten design for improved immunorecognition of phenylbutazone in herbal tea by lateral flow immunoassay.

Talanta·2026
Same author

Regulation of gut epithelial barrier and tuft/goblet cell responses by microbiome repair: Opportunities and future directions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A linear clinical prediction model and nomogram evaluating risk of portal vein thrombosis in liver cirrhosis.

BMC gastroenterology·2026
Same author

MIL-101(Cr) disrupts algal carbon fixation by intercepting photosynthetic electron flow: Implications for aquatic primary productivity.

Journal of hazardous materials·2026
Same author

Immunomodulatory functions of ginsenosides in skin diseases: molecular mechanisms and therapeutic prospects.

Frontiers in pharmacology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jul 2, 2026

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer
08:54

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Published on: June 13, 2019

11.5K

前进工程器官发育和癌症治疗与光遗传学.

Mayesha Sahir Mim, Stephen Cini, Caitlin Frank

    bioRxiv : the preprint server for biology
    |June 6, 2025
    PubMed
    概括
    此摘要是机器生成的。

    研究人员使用光遗传学来控制Drosophila翅膀中的细胞信号,发现光可以精确调节器官大小甚至瘤生长,提供新的治疗策略.

    更多相关视频

    Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
    08:36

    Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

    Published on: October 24, 2019

    11.8K
    Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging
    12:49

    Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging

    Published on: March 28, 2020

    8.4K

    相关实验视频

    Last Updated: Jul 2, 2026

    Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer
    08:54

    Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

    Published on: June 13, 2019

    11.5K
    Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
    08:36

    Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

    Published on: October 24, 2019

    11.8K
    Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging
    12:49

    Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging

    Published on: March 28, 2020

    8.4K

    科学领域:

    • 发展生物学 发展生物学
    • 视觉遗传学 视觉遗传学
    • 细胞信号传递 细胞信号传递

    背景情况:

    • 强大的器官生长控制对生存至关重要,其失调导致癌症等疾病.
    • 了解精确的器官大小调节机制仍然是一个重大挑战.
    • 光遗传工具提供了非侵入性的方法来控制体内细胞信号传输.

    研究的目的:

    • 通过光遗传学研究生物电和化学线索如何调节器官生长.
    • 探索细胞内信号传递在多虫翅膀发育中的作用.
    • 为了确定光学刺激参数是否可以控制器官大小和瘤形态.

    主要方法:

    • 利用红光激活的通道罗多普辛,CsChrimson,在Drosophila melanogaster的翅膀上皮.
    • 系统地改变光强度和激活动态以刺激细胞内信号传递.
    • 开发了一个计算模型来解释动力学,包括间隙连接和电压导入通道活动.
    • 与瘤基因RasV12共同表达的CsChrimson用于研究瘤组织的反应.

    主要成果:

    • 根据光刺激参数确定了基于器官大小的双相调节.
    • 证明特定的光模式 (暗,脉动) 促进器官生长和细胞增殖.
    • 表明强烈,长时间的光线会诱导细胞死亡和形态异常.
    • 证实光学刺激可以调节瘤组织形态和生长.

    结论:

    • 通过光遗传学精确控制细胞信号传递,可以动态调节器官大小.
    • 这些发现为剖析器官生成中的生理信号提供了一个框架.
    • 这种方法为癌症治疗和再生医学提供了潜在的翻译见解.