什么时候微生物交叉养在进化上是稳定的?
Jamie Alcira Lopez1,2,3, Bo Liu4,5, Zhiyuan Li6,7
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, New Jersey 08544, USA.
bioRxiv : the preprint server for biology
|June 6, 2025
概括
微生物共享代谢副产品的废物产品交叉养是常见的,但不太了解. 这项研究揭示了一般化的细胞内代谢物毒性作为使稳定的交叉养微生物联盟成为可能的关键机制.
科学领域:
- 微生物生态学 微生物生态学
- 进化生物学 进化生物学
- 生物化学 生物化学
背景情况:
- 交叉养,生物之间代谢物的交换,在微生物群落中很普遍.
- 废物交叉养,一种单向相互作用,是一种常见的形式,其中一种微生物的废物支持另一种微生物的生长.
- 废物产品交叉养的进化持续性,尽管有单个生物体效率的潜力,仍然不清楚.
研究的目的:
- 调查废物产品交叉养的进化稳定性.
- 确定解释为什么微生物联盟参与交叉养的机制.
- 了解促进交叉食相互作用稳定的条件.
主要方法:
- 使用微生物新陈代谢最小模型对交叉养进化的分析.
- 多步式能量提取的热力学正确配方.
- 研究具有复杂生长功能的模型,以确定稳定机制.
主要成果:
- 在最小代谢模型中,交叉养在进化上并不稳定.
- 普遍的细胞内代谢物毒性被确定为交叉养稳定的新机制.
- 与细胞内代谢物水平的非线性缩放增长惩罚促进交叉养.
结论:
- 一般化的细胞内代谢物毒性可以稳定废物交叉养联盟.
- 联盟可以分配有毒代谢物负担,以提高集体效率.
- 交叉养稳定机制可能导致复杂的种群动态,包括生物质不连续性.
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