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Updated: Sep 19, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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酸化使病毒凝聚物的全性控制成为可能

Julia Acker1, Xinyu Wang1, Daniel Desirò1

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, CB3 0AS, Cambridge, UK.

bioRxiv : the preprint server for biology
|June 6, 2025
PubMed
概括

病毒复制依赖于内在无序的蛋白质 (IDP) 形成凝聚物. 罗塔病毒NSP5蛋白质变体表现出多样化的相分离能力,酸化在跨菌株的凝聚物形成中起着关键作用.

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Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
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Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Allosteric Regulation

Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
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Amplifying Signals via Enzymatic Cascade

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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