相关实验视频

Updated: Jan 18, 2026

Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique
06:32

Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique

Published on: March 9, 2022

2.1K

ARID1A调节了人类正规的BAF复合体的色素八位体转移活性

Naoe Moro, Yukiko Fujisawa-Tanaka, Shinya Watanabe

    bioRxiv : the preprint server for biology
    |June 6, 2025
    PubMed
    概括

    在ARID1A中发生的突变,这是染色质重塑复合物的子单元,在癌症中很常见. 这项研究揭示了ARID1A对于组织素八聚体转移至关重要,这是预防癌症的关键功能.

    更多相关视频

    Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer11:33

    Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer

    Published on: October 14, 2022

    2.0K
    In Vitro Characterization of Histone Chaperones using Analytical, Pull-Down and Chaperoning Assays08:16

    In Vitro Characterization of Histone Chaperones using Analytical, Pull-Down and Chaperoning Assays

    Published on: December 29, 2021

    3.2K

    相关概念视频

    Histone Modification02:32

    Histone Modification

    The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
    Acetylation
    The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
    15.9K
    Histone Modification02:32

    Histone Modification

    4.4K
    Histone Variants at the Centromere02:30

    Histone Variants at the Centromere

    Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
    4.9K
    Spreading of Chromatin Modifications02:25

    Spreading of Chromatin Modifications

    The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
    Writers
    The writer...
    9.3K
    The Nucleosome Core Particle01:12

    The Nucleosome Core Particle

    Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
    Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
    2.2K
    The Nucleosome Core Particle02:10

    The Nucleosome Core Particle

    Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
    The paradox
    Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
    14.1K