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Updated: May 30, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

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黑猩猩和人类的ApoE异型在刺激神经元分化方面有所不同,这与与大脑发育和衰老相关的结构预测一致

Max A Thorwald, Mafalda Cacciottolo, Xiaogang Hou

    bioRxiv : the preprint server for biology
    |June 6, 2025
    PubMed
    概括

    黑猩猩的ApoE与人类的ApoE3不同,其结构和功能与ApoE4相似,影响神经元发育. 这种进化差异可能解释了为什么黑猩猩患阿尔茨海默病 (AD) 的风险较低.

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