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Updated: Sep 19, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Published on: August 23, 2024

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DNA2和FANCM在破坏TERRA R循环和抑制ALT端粒的复制应激方面通过两个不同的途径发挥作用

Ashwin Ragupathi, Heba Z Abid, Yun Chen

    bioRxiv : the preprint server for biology
    |June 6, 2025
    PubMed
    概括

    在替代延长端粒 (ALT) 癌症中不激活DNA2会增加复制压力和DNA损伤. 同时准DNA2和FANCM显示ALT+细胞的合成致死性,提供了一种新的癌症治疗策略.

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