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Updated: Sep 19, 2025

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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在MR1抗原结合槽外的突变差异性抑制了外源抗原的呈现

Corinna A Kulicke1, Chance Lemon1, Jason R Krawic2

  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR 97239, USA.

bioRxiv : the preprint server for biology
|June 6, 2025
PubMed
概括

与MHC I类相关的蛋白1 (MR1) 向粘膜相关的不变T细胞 (MAIT细胞) 呈现微生物代谢物. 在MR1中发生的突变会影响其细胞表面呈现和抗原呈现,而B2M会限制外源抗原呈现.

关键词:
一个 MAIT 细胞.有MR1限制的T细胞.这就是T细胞.抗原呈现的呈现方式.细胞免疫反应的细胞免疫反应.粘膜免疫学 粘膜免疫学

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