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向Regnase-1释放了对骨髓瘤的CAR T细胞抗瘤活性,并创造了一个促炎性瘤微环境

Adeleye O Adeshakin1, Hao Shi2, S Scott Perry1

  • 1Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.

bioRxiv : the preprint server for biology
|June 6, 2025
PubMed
概括

删除CAR T细胞中的Regnase-1增强了它们的抗瘤活性,并促进了促炎性瘤微环境. 这种方法通过重塑免疫环境,改善了对固体瘤的CAR T细胞疗法.

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