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Updated: Jan 18, 2026

Expanding the Toolkit for In Vivo Imaging of Axonal Transport
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Expanding the Toolkit for In Vivo Imaging of Axonal Transport

Published on: December 23, 2021

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内基因组转录学揭示了Cajal尸体的贩运到多个体的身体

Jasleen Singh, Justin Krish Williams, Quinn Elliott

    bioRxiv : the preprint server for biology
    |June 6, 2025
    PubMed
    概括

    研究人员发现,核小型调节性RNA传输到外体的源头 - - 多胞体 (MVB). 这一过程需要ESCRT机械和VPS34,它提供了通过内溶酶体路径进行核RNA循环的机制.

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    Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells11:05

    Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

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    Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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    Recycling Endosomes and Transcytosis00:58

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    The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
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    Transport Across the Golgi01:26

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    While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
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    Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
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