之前的COVID-19感染会增加退化的卵细胞,但不会影响试管婴儿的结果:一项前性队列研究
Huijun Chen1,2,3, Hongxin Guo1, Qi Zhao1
1Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Frontiers in endocrinology
|June 6, 2025
概括
从COVID-19中康复的妇女显示,退化的卵细胞略有增加,但对试管婴儿成功率或怀孕率没有显著影响. 感染后的治疗时间不是体外受精的障碍.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 传染性疾病 传染性疾病
- 辅助生殖技术 辅助生殖技术
背景情况:
- 2019年冠状病毒病 (COVID-19) 的全球影响延伸到生殖健康,新出现的证据表明可能对生育能力产生影响.
- 之前的研究表明,COVID-19感染与低生育率或不孕症之间可能存在联系.
研究的目的:
- 调查前COVID-19感染对接受体外受精 (IVF) 的妇女卵细胞和胚胎质量的影响.
- 评估COVID-19恢复对临床怀孕率和其他试管婴儿结果的影响.
主要方法:
- 一项前性观察队列研究,将781名从COVID-19中康复的妇女与接受标准IVF治疗的388名未感染的对照进行比较.
- 对卵细胞和胚胎质量参数的分析,包括退化的卵细胞的比率.
- 评估二次结果,如临床怀孕,植入,流产,宫外怀孕和正在进行的怀孕率.
主要成果:
- 与对照组相比,COVID-19康复组呈现出统计学上显著的较高数量的退化的卵细胞 (P=0.035),即使经过对混因素的调整.
- 在其他卵细胞和胚胎质量参数方面,两组之间没有发现显著差异.
- 临床怀孕率和其他关键生殖结果在有和没有COVID-19病史的妇女之间仍然相似.
结论:
- 之前的COVID-19感染与卵细胞退化的风险略有增加有关,但不会显著影响整体IVF成功或怀孕结果.
- 自COVID-19恢复以来的时间似乎没有影响试管婴儿的结果,这表明治疗可以在没有不必要的延迟的情况下进行.
- 这些发现为计划从COVID-19中恢复后进行生育治疗的个人提供了保证.
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