由外部移动波力驱动的虫状链的活态动力学
Fabio Cecconi1,2, Andrea Puglisi3, Massimiliano Viale3,4
1CNR-Institute for Complex Systems, Via dei Taurini 19, 00185 Rome, Italy. fabio.cecconi@cnr.it.
Soft matter
|June 6, 2025
概括
这项研究使用状链 (WLC) 模型模拟半灵活的鞭毛,以了解外部移动波扰动如何与内在曲刚性相互作用,从而导致鞭毛跳动模式.
科学领域:
- 生物物理学的生物物理.
- 理论力学 理论力学 理论力学
- 细胞生物学 细胞生物学
背景情况:
- 细胞的鞭毛和眼通过复杂的跳动模式产生运动.
- 分子电机在轴膜内产生活力,驱动这些运动.
- 了解鞭毛推进的机制对于细胞运动性研究至关重要.
研究的目的:
- 在移动波扰动下开发半柔性鞭毛的简化理论.
- 为了研究外部力和内在丝刚度之间的相互作用.
- 确定控制鞭毛波形选择和动态的关键参数.
主要方法:
- 将鞭毛模拟为一个类似虫的链条 (WLC).
- 应用移动波扰动来模拟分子运动活动.
- 对WLC对干扰的反应进行系统分析,以研究构造选择.
主要成果:
- 这项研究探讨了应用扰动和鞭毛体内固有的曲刚度之间的竞争.
- 确定了这种相互作用如何导致特定的形状和时空跳动力学.
- 研究了影响机械波形形状的关键参数.
结论:
- 该WLC模型提供了对鞭毛击机制的见解.
- 这一框架有助于解释外力如何为运动性选择形状.
- 这些发现与理解精子尾巴,毛和真核细胞鞭毛有关.
相关概念视频
Forced Oscillations
6.8K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
6.8K
Mechanism of Lamellipodia Formation
2.8K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.8K
Travelling Waves
5.6K
A wave is a disturbance that propagates from its source, repeating itself periodically, and is typically associated with simple harmonic motion. Mechanical waves are governed by Newton's laws and require a medium to travel. A medium is a substance in which a mechanical wave propagates, and the medium produces an elastic restoring force when it is deformed.
Water waves, sound waves, and seismic waves are some examples of mechanical waves. For water waves, the wave propagation medium is...
Water waves, sound waves, and seismic waves are some examples of mechanical waves. For water waves, the wave propagation medium is...
5.6K
Actin Polymerization and Cell Motility
5.5K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.5K
Non-conservative Forces
8.2K
Non-conservative forces are dissipative forces such as friction or air resistance. These forces take energy away from a system as it progresses. Unlike conservative forces, non-conservative forces do not have potential energy associated with them. This is because the energy is lost to the system and cannot be turned into useful work later.
Also unlike their conservative counterparts, they are path-dependent; where the object starts and stops does matter. For example, a grinding wheel applies a...
Also unlike their conservative counterparts, they are path-dependent; where the object starts and stops does matter. For example, a grinding wheel applies a...
8.2K
Speed of a Transverse Wave
1.8K
The speed of a wave depends on the characteristics of the medium. For example, in the case of a guitar, the strings vibrate to produce the sound. The speed of the waves on the strings and the wavelength determine the frequency of the sound produced. The strings on a guitar have different thicknesses but may be made of similar material. They have different linear densities, and the linear density is defined as the mass per length.
One of the key properties of any wave is the wave speed. Light...
One of the key properties of any wave is the wave speed. Light...
1.8K


