狗患有未知起源的脑膜大脑炎的大脑缩
Rita Gonçalves1,2, Gemma Walmsley1,2, Thomas W Maddox1,2
1Department of Veterinary Science, Small Animal Teaching Hospital, University of Liverpool, Leahurst, Neston, UK.
Journal of veterinary internal medicine
|June 6, 2025
概括
大脑缩可能发生在狗的脑膜炎来源不明 (MUO),由重复MRI扫描显示. 这种大脑缩与较差的结果有关,可能表明需要更积极的治疗策略.
科学领域:
- 兽医神经学 兽医神经学
- 神经成像是一种神经成像.
背景情况:
- 有限的信息重复磁共振成像 (MRI) 在狗脑膜大脑炎未知来源 (MUO) 的发现是有限的.
- 目前尚不清楚犬类MUO病例中是否会发生大脑缩.
研究的目的:
- 调查诊断为MUO的狗中大脑缩的发生情况.
- 评估大脑缩与这些狗的生存率或疾病复发之间的关联.
主要方法:
- 一项回顾性研究涉及23只患有MUO的狗,这些狗经历了至少六个月间隔的两次脑部MRI扫描.
- 量化MRI指标,包括脑间粘附与脑高度比率 (ITr),侧心室与脑高度比率 (LVr),双度比率 (BCR) 和全副细胞大脑体积 (TPBV),测量并比较扫描之间.
主要成果:
- 13只狗复发了,在研究期间有4只狗死亡. 所有测量的MRI变量在两个扫描之间显示出显著的变化.
- 增加的全副细胞大脑体积 (TPBV) 与延长的存活率有关 (OR=1.59,P=0.047). 没有特定的MRI变量与复发相关.
- 在六只狗中,在重复的MRI上观察到新的或增强对比的病变,其中五只随后复发.
结论:
- 大脑缩很可能存在于MUO的狗身上,并且与不良结果相关.
- 在重复的MRI上出现新的或增强对比度的病变可能预测临床复发,这表明需要加强治疗方法.
相关概念视频
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...